Peptides before surgery and anesthesia
What each label or study says about surgery and anesthesia, such as the GLP-1 warning about stomach contents during sedation.
- Compounds
- 68
- From labels
- 8
- From human studies
- 2
- Precautions
- 58
- No study or data
- 0
Approved drugs come first in each group. This summarizes each compound’s own page; it isn’t medical advice, and a doctor or pharmacist can answer for a specific person.
From a product label 8
- ExenatideApproved drug
- LabelIt slows stomach emptying, and rare reports describe stomach contents entering the lungs under anesthesia or deep sedation. The label says to tell the care team beforehand; whether pausing the drug helps is unknown.
- LiraglutideApproved drug
- LabelIt slows stomach emptying, and rare reports describe stomach contents entering the lungs under anesthesia or deep sedation. The labels say to tell the care team beforehand; whether pausing the drug helps is unknown.
- OrforglipronApproved drug
- LabelIt slows stomach emptying, and rare reports describe stomach contents entering the lungs under anesthesia or deep sedation with GLP-1 drugs. The label says to tell the care team beforehand; whether pausing helps is unknown.
- OxytocinApproved drug
- LabelThe US label reports severe high blood pressure when oxytocin followed a blood-vessel-narrowing drug given with caudal (lower-spine) anesthesia, and low blood pressure with cyclopropane anesthesia. Tell the surgical team about any use.
- SemaglutideApproved drug
- LabelIt slows stomach emptying, and rare reports describe stomach contents entering the lungs under anesthesia or deep sedation. The labels say to tell the care team beforehand; whether pausing the drug helps is unknown.
- SS-31Approved drug
- LabelThe label gives no surgery advice. In label studies, infused elamipretide didn’t change how aspirin, clopidogrel or heparin affected clotting. Tell the surgical team about it.
- TesamorelinApproved drug
- LabelThe patient leaflet says to tell the prescriber about planned heart or stomach surgery. Growth hormone has raised deaths in critical illness after such surgery, so the label advises considering stopping it in critically ill patients.
- TirzepatideApproved drug
- LabelIt slows stomach emptying, and rare reports describe stomach contents entering the lungs under anesthesia or deep sedation. The labels say to tell the care team beforehand; whether pausing the drug helps is unknown.
From human studies 2
- DSIPApproved drug
- TrialIn a 24-woman surgical trial, IV DSIP raised heart rate and made anesthesia lighter rather than deeper. Tell the surgical team about any compound you use.
- IpamorelinHuman studies
- TrialTested only as an IV drip after bowel surgery, without benefit; serious complications were similar to placebo (17.9% vs 15.5%). Tell the surgical team about any injected compound.
A precaution, not studied 58
- CerebrolysinApproved drug
- PrecautionNo anesthesia data. The labels warn of rare seizures and of blood pressure rises with MAO inhibitors; tell the surgical team about any injected compound.
- GHRP-2Approved drug
- PrecautionNo data; tell the surgical team about any injected compound.
- GlutathioneApproved drug
- PrecautionNo data; tell the surgical team about any injected compound.
- GonadorelinApproved drug
- PrecautionNo data; tell the surgical team about any injected compound.
- hCGApproved drug
- PrecautionNo label advice; tell the surgical team about any injected compound. In women on fertility treatment, blood clots are a listed risk, and surgery adds to clot risk.
- L-CarnitineApproved drug
- PrecautionNo data on surgery. Tell the surgical team about any injected compound, especially with warfarin, since carnitine can raise INR, a clotting test.
- MazdutideApproved drug
- PrecautionNo data. Related drugs slow stomach emptying, and their labels warn that stomach contents can enter the lungs under anesthesia; tell the surgical team about any injected compound.
- Melanotan 1Approved drug
- PrecautionNo label guidance on surgery. The EU label notes blood thinners may increase bruising or bleeding at the implant site; tell the surgical team about the implant.
- PT-141Approved drug
- PrecautionNo label advice. Each dose briefly raises blood pressure and may slow stomach emptying; tell the surgical team about any injected compound.
- SelankApproved drug
- PrecautionNo data in surgery. The label reports no interaction with barbiturate sedatives; tell the surgical team about any compound you use, including nose drops.
- SemaxApproved drug
- PrecautionThe 0.1% label covers recovery after brain surgery and anesthesia. FDA’s 2026 review flagged a possible anticlotting effect and bleeding risk; tell the surgical team about any compound you use.
- ThymalinApproved drug
- PrecautionNo data in the label; tell the surgical team about any injected compound.
- Thymosin Alpha-1Approved drug
- PrecautionNo published data. Indonesia’s label rules it out during deliberate immune suppression, as after organ transplants; tell the surgical team about any injected compound.
- TriptorelinApproved drug
- PrecautionNo label advice on surgery. A depot keeps working for weeks to months and can’t be removed; tell the surgical team, especially as it can lengthen the QT interval, a heart-rhythm measure.
- VIPApproved drug
- PrecautionNo data. VIP widens blood vessels, and IV infusions often lowered blood pressure; tell the surgical team about any injected or nasal compound.
- AOD9604Human studies
- PrecautionNo data; tell the surgical team about any injected compound.
- ARA-290Human studies
- PrecautionNo data; tell the surgical team about any injected compound.
- ArgirelineHuman studies
- PrecautionNo data; tell the surgical team about any injected compound.
- CagrilintideHuman studies
- PrecautionNo data for cagrilintide. Amylin slows stomach emptying, and GLP-1 labels warn of stomach contents entering the lungs under anesthesia. Tell the surgical team about any injected compound.
- CJC-1295 with DACHuman studies
- PrecautionNo data; tell the surgical team about any injected compound. A single dose acts for about a week.
- DihexaHuman studies
- PrecautionNo data; tell the surgical team about any compound you take, including unapproved ones.
- GHK-CuHuman studies
- PrecautionNo data; tell the surgical team about any injected compound.
- GHRP-6Human studies
- PrecautionNo data; tell the surgical team about any injected compound.
- HexarelinHuman studies
- PrecautionNo data; tell the surgical team about any injected compound.
- Kisspeptin-10Human studies
- PrecautionNo data; tell the surgical team about any injected compound.
- LarazotideHuman studies
- PrecautionNo data; tell the surgical team about any unapproved medicine being taken.
- LL-37Human studies
- PrecautionNo data; tell the surgical team about any injected compound.
- MatrixylHuman studies
- PrecautionNo data; tell the surgical team about any injected compound.
- Melanotan 2Human studies
- PrecautionNo data; tell the surgical team about any injected compound. Bremelanotide’s label says it may slow stomach emptying and briefly raises blood pressure after each dose.
- MK-677Human studies
- PrecautionNo data; tell the surgical team about any unapproved compound being taken, since it raises blood sugar and can raise blood pressure.
- NAD+Human studies
- PrecautionNo data; tell the surgical team about any injected compound.
- RetatrutideHuman studies
- PrecautionNo data. Related drugs slow stomach emptying, and their labels warn that stomach contents can enter the lungs under anesthesia; tell the surgical team about any injected compound.
- SermorelinHuman studies
- PrecautionNo data; tell the surgical team about any injected compound.
- SNAP-8Human studies
- PrecautionNo data; tell the surgical team about any injected compound.
- SurvodutideHuman studies
- PrecautionNo data. Related drugs slow stomach emptying, and their labels warn that stomach contents can enter the lungs under anesthesia; tell the surgical team about any injected compound.
- TesofensineHuman studies
- PrecautionNo data. It raises heart rate and stays in the body for weeks after stopping, so tell the surgical team about any recent use.
- Thymosin Beta-4Human studies
- PrecautionNo data; tell the surgical team about any injected compound.
- 5-Amino-1MQPreclinical
- PrecautionNo data; tell the surgical team about any unapproved compound being taken, by mouth or by injection.
- AdamaxPreclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- AHK-CuPreclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- BPC-157Preclinical
- PrecautionNo human data. FDA noted altered clotting times in 28-day animal tests; tell the surgical team about any injected compound.
- CartalaxPreclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- CJC-1295 (no DAC)Preclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- EpithalonPreclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- Follistatin-344Preclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- FOXO4-DRIPreclinical
- PrecautionNo data. In mice, senescent cells help wounds close, so clearing them could in theory slow healing; tell the surgical team about any injected compound.
- HGH Fragment 176-191Preclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- HumaninPreclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- IGF-1 DESPreclinical
- PrecautionNo data. Fasting before surgery raises the risk of low blood sugar with IGF-1 drugs; mecasermin’s label says not to dose when a meal is skipped. Tell the surgical team.
- IGF-1 LR3Preclinical
- PrecautionNo data. Fasting before surgery raises the risk of low blood sugar with IGF-1 drugs; mecasermin’s label says not to dose when a meal is skipped. Tell the surgical team.
- KPVPreclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- MGFPreclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- MOTS-cPreclinical
- PrecautionNo data; tell the surgical team about any injected compound. It lowered blood sugar in animals, a concern during fasting before surgery.
- PE-22-28Preclinical
- PrecautionNo data. Mice lacking TREK-1 resisted inhaled anesthetics, so a TREK-1 blocker could in theory affect anesthesia; tell the surgical team about any injected compound.
- PEG-MGFPreclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- PinealonPreclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- SLU-PP-332Preclinical
- PrecautionNo data; tell the surgical team about any injected compound.
- TB-500Preclinical
- PrecautionNo data; tell the surgical team about any injected compound.
Sources
Each answer comes from the compound’s own page, where its sources are listed.