Injected course
Community- Dose
- 1–2 mg
- How often
- Once daily, usually mornings
- How long
- 10–20 days
Where injection guides overlap. Repeated every 2–6 months, depending on the guide.
Draw 20–40 units10 mg + 2 mL
PreclinicalShort bioregulator peptide
Pinealon
Glu-Asp-Arg (EDR)
- Common dose
- ~1 mg daily for 10–20 days
- Cycle
- 2-week course, about every 6 months
- Vial sizes
- 10 mg
- Typical draw
- 20 units10 mg with 2 mL, 1 mg
A synthetic three-amino-acid peptide from the Russian bioregulator family, studied in cells and rats for antioxidant and brain-protective effects.
Evidence. Cell and rodent studies, plus small, low-quality human reports in Russian journals. No controlled human trials.
Status
- Approval
- Not approved as a drug in the US or EU.
- Sport (WADA 2026)
- Likely banned in sportNot named on WADA’s 2026 list, but its S0 rule bans drugs with no current human approval anywhere, at all times.
Sport status follows the WADA Prohibited List in force since January 1, 2026; athletes should confirm with their anti-doping organization. Checked October 5, 2026.
Protocol
Community
Injected: 1–2 mg once daily for 10–20 days is where most guides overlap.
Community
Oral or nasal: some guides use 5–20 mg a day for 10 days, assuming most is broken down before it’s absorbed. No human data test that. Across all guides, doses differ about 100-fold.
Trial
Nazimko 2012
Oral: 100 mcg twice daily for 2 weeks in a small Russian report on train crews. Not a controlled trial.
- Frequency
- Once daily during a course
- Route
- Subcutaneous injection (community)
- Cycle
- 10–20 day courses, 1–3 times a year.
2-week course, about every 6 months, shown over 26 weeks
Common protocols
The ways Pinealon is most often run, each tagged with where it comes from.
Oral or nasal course
Community- Dose
- 10 mg (range 5–20 mg)
- How often
- Once daily
- How long
- 10 days
Guides use higher oral doses on the untested assumption that most is broken down before it’s absorbed. The one published oral report used 100 mcg twice daily.
Taking it
Where it goes
Subcutaneous in the abdomen, thigh or upper arm, rotating sites; mornings are most common. Some guides use nasal drops or oral forms instead.
If you miss a dose
No published guidance. Resume the next day and don’t double up.
What to expect
- During a course
Guides claim subtle support for focus, memory and sleep rhythm. These claims rest on animal work and small Russian observations.
Community - After a course
No controlled human data on how long any effect lasts. Guides simply repeat the course every few months.
Community
Side effects and what to do
Injection-site soreness or redness
Usually mild; rotate sites. Spreading redness, heat or pus means see a doctor.
No serious side effects reported, but data are thin
Reports come from one Russian group; absence of reports isn’t proof of safety.
Allergic reaction (possible with any injected peptide)
Stop and get emergency care for hives, facial swelling or trouble breathing.
Stop and get medical help
Stop and get medical help for hives, swelling of the face or throat, trouble breathing, or a hot, spreading or pus-filled injection site.
Tracking and pairing
Worth tracking
No established labs or checks.
Often paired with
- Epithalon
Often run together in Russian bioregulator protocols (brain plus pineal). No trial has tested the combination.
Human studies
2 key published human studies, with how many people took part. Animal studies aren’t listed here.
-
Authors report better biological-age markers in adults aged 41 to 83 with organic brain syndrome; a related peptide, Vesugen, did better.
- Design
- Small clinical study, controls and blinding not described (Russian)
- Dose
- Not stated in abstract
- Length
- Not stated in abstract
Meshchaninov et al., Adv Gerontol 2015 (Russian), PMID 26390612
-
Authors report better biological-age and adaptation scores; the abstract gives no numbers.
- Design
- Small study in train crew workers, controls not described (Russian)
- Dose
- 100 micrograms by mouth twice daily
- Length
- 2 weeks
Nazimko et al., Adv Gerontol 2012 (Russian), PMID 22708445
Mixing your vial
| Vial | Water | Common dose | Draw | Strength | Action |
|---|---|---|---|---|---|
| 10 mg | 2 mL | 1 mg | 20 units (0.20 mL) | 5 mg/mL |
Dose chart
10 mg vialSyringe units for common doses at different water volumes. Select a cell to open it in the calculator.
| Dose | Water added | ||
|---|---|---|---|
| 1 mL | 2 mL | 3 mL | |
| 0.1 mg | |||
| 0.25 mg | |||
| 0.5 mg | |||
| 1 mg | |||
| 2.5 mg | |||
| 5 mg | |||
| 10 mg | |||
U-100 insulin syringe: 100 units is 1 mL. Draws over 100 units show in mL. Faded values are under 2 units, which is hard to measure. Check that your vial holds the larger volumes.
Datasheet
- Half-life
- No reliable value has been published.
- Type
- Peptide, 3 amino acids
- Molecular weight
- 418.4 g/mol
- Formula
- C15H26N6O8
- Sequence
- EDR
- Storage before use
- Freezer (−20 °C) for long-term storage; fridge is fine for short periods.
- After mixing or opening
- Refrigerate (2–8 °C) after mixing and use within about 4 weeks.
- Molecule: PubChem CID 10273502
- Storage: Community Common practice for research peptide vials; no approved product label exists
Cautions
- No controlled human trials.
- Community doses vary about 100-fold.
Questions
What is Pinealon?
A synthetic three-amino-acid peptide from the Russian bioregulator family, studied in cells and rats for antioxidant and brain-protective effects.
Is Pinealon FDA-approved?
Not approved as a drug in the US or EU.
What is the usual Pinealon dose?
From community reports, not established: Injected: 1–2 mg once daily for 10–20 days is where most guides overlap. Oral or nasal: some guides use 5–20 mg a day for 10 days, assuming most is broken down before it’s absorbed. No human data test that. Across all guides, doses differ about 100-fold. These are the amounts sources reference, not recommendations.
How much water do I mix Pinealon with?
There’s no single right amount, because the water only sets the strength. With 2 mL of bacteriostatic water in a 10 mg vial, the strength is 5 mg/mL, so 1 mg is 20 units on a U-100 insulin syringe. More water makes small doses easier to measure. The dose chart above shows other volumes.
How should Pinealon be stored?
Before mixing: Freezer (−20 °C) for long-term storage; fridge is fine for short periods. Refrigerate (2–8 °C) after mixing and use within about 4 weeks. This is common practice; no product label covers it.
Is Pinealon banned in sport?
Probably. Not named on WADA’s 2026 list, but its S0 rule bans drugs with no current human approval anywhere, at all times.
Has Pinealon been studied in people?
Yes. The human studies section lists 2 published studies. Among them, from 2015: Authors report better biological-age markers in adults aged 41 to 83 with organic brain syndrome; a related peptide, Vesugen, did better.
Sources
- Pinealon (Wikipedia)
- Nazimko et al., train crews given Pinealon (Adv Gerontol 2012, Russian) PMID 22708445
Doses tagged Community come from public dosing guides and user reports, checked against at least two of them. Those sites aren’t named here because many of them sell peptides or earn commissions on them.