Start
Community- Dose
- 50 mg by mouth
- How often
- Once daily, morning
- How long
- Weeks 1–2
The usual starting amount in guides, to check for sleep or stomach problems.
PreclinicalNNMT inhibitor (small molecule)
5-Amino-1MQ
5-amino-1-methylquinolinium
- Common dose
- No set injectable dose
- Cycle
- 8 weeks on, 4 off
- Vial sizes
- 10, 50 mg
A small molecule, not a peptide, that blocks the enzyme NNMT. In obese mice it reduced fat mass and body weight.
Evidence. Cell and animal studies only, including a rat study of how the body absorbs and clears it. No published human safety or dosing data.
Status
- Approval
- Not approved as a drug in the US or EU.
- Sport (WADA 2026)
- Likely banned in sportNot named on WADA’s 2026 list, but its S0 rule bans drugs with no current human approval anywhere, at all times.
Sport status follows the WADA Prohibited List in force since January 1, 2026; athletes should confirm with their anti-doping organization. Checked October 5, 2026.
Protocol
Community
Oral: 50–150 mg per day, often starting at 50 mg.
Community
Injectable: no consensus. Reports conflict, and oral amounts don’t translate to injections.
- Frequency
- Once daily
- Route
- Oral in most community use; injection is less common
- Timing
- Morning. Evening doses are anecdotally linked to poor sleep.
- Cycle
- 8–12 weeks on, 4–6 weeks off.
8 weeks on, 4 off, shown over 26 weeks
Common protocols
The ways 5-Amino-1MQ is most often run, each tagged with where it comes from.
Standard
Community- Dose
- 100 mg by mouth
- How often
- Once daily, morning
- How long
- 8–12 weeks, then 4–6 weeks off
Guides top out at 150 mg a day. No human dose has been tested.
Split dose
Community- Dose
- 50 mg twice a day by mouth
- How often
- Morning and early afternoon
- How long
- 8–12 weeks
Keeps the second dose away from bedtime.
Taking it
Where it goes
Usually swallowed as capsules. Injectable versions go under the skin with sites rotated and can sting. Oral and injected amounts are not interchangeable.
If you miss a dose
No official guidance. Guides say to skip it and take the next dose as usual, and not to double up, since safe limits are unknown.
What to expect
- Weeks 1–2
Most guides start at 50 mg to check for sleep or stomach problems before going higher.
Community - Any time
No human study has measured results or timing. Reports of fat loss are anecdotal.
Community
Side effects and what to do
Trouble sleeping
Take it in the morning or early afternoon, not near bedtime. Lower the dose if it persists.
Faster resting heart rate or feeling warm
Anecdotal. Lower the dose or stop if it persists; stop at once with palpitations or chest pain.
Stomach upset or nausea
Reported when starting too high. Start at 50 mg.
Stinging at the injection site
Injectable forms only. Rotate sites.
Stop and get medical help
Chest pain, palpitations or a racing heart that won’t settle, fainting, severe stomach pain, or yellow skin or eyes. Stop and get medical help.
Tracking and pairing
Worth tracking
- Resting heart rate
- Sleep
- Liver enzymes (ALT, AST) before starting
Often paired with
- SLU-PP-332
Sold together in vendor fat-loss blends. Each targets energy use in a different way. Never tested together in people.
Human studies
No published human studies of 5-Amino-1MQ turned up in our October 2026 review. The evidence note at the top of this page sums up what is known.
Mixing your vial
| Vial | Water | Common dose | Draw | Strength | Action |
|---|---|---|---|---|---|
| 10 mg | 2 mL | – | – | 5 mg/mL | |
| 50 mg | 5 mL | – | – | 10 mg/mL |
Water solubility is limited. Mix gently and discard the vial if it stays cloudy.
There’s no established per-injection amount for 5-Amino-1MQ, so the table shows strength only.
Datasheet
- Half-life
- about 4 to 7 hours in rats Animal3.8 hours after IV and 6.9 hours after oral dosing in rats; oral bioavailability about 38%. No human data.
- Type
- Small molecule
- Molecular weight
- 159.2 g/mol
- Formula
- C10H11N2+
- Storage before use
- Freezer for long-term storage; keep the vial sealed, dry and out of light.
- After mixing or opening
- Fridge (2–8 °C) after mixing; use within about 4 weeks.
- Half-life: Awosemo et al., J Pharm Biomed Anal 2021, PMID 34304009
- Molecule: PubChem CID 950107 (cation). Salt forms weigh more: iodide CID 66522933 is 286.1 g/mol, chloride CID 176507677 is 194.7 g/mol.
- Storage: Community Common community practice; no label or manufacturer storage data exist for this compound.
Cautions
- No human safety data at any dose.
- Anecdotal reports: insomnia, raised heart rate, stinging on injection.
- Oral and injected amounts are not interchangeable.
Questions
What is 5-Amino-1MQ?
A small molecule, not a peptide, that blocks the enzyme NNMT. In obese mice it reduced fat mass and body weight.
Is 5-Amino-1MQ FDA-approved?
Not approved as a drug in the US or EU.
What is the usual 5-Amino-1MQ dose?
From community reports, not established: Oral: 50–150 mg per day, often starting at 50 mg. Injectable: no consensus. Reports conflict, and oral amounts don’t translate to injections. These are the amounts sources reference, not recommendations.
What is the half-life of 5-Amino-1MQ?
About 4 to 7 hours in rats, measured in animals, not people. 3.8 hours after IV and 6.9 hours after oral dosing in rats; oral bioavailability about 38%. No human data.
How should 5-Amino-1MQ be stored?
Before mixing: Freezer for long-term storage; keep the vial sealed, dry and out of light. Fridge (2–8 °C) after mixing; use within about 4 weeks. This is common practice; no product label covers it.
Is 5-Amino-1MQ banned in sport?
Probably. Not named on WADA’s 2026 list, but its S0 rule bans drugs with no current human approval anywhere, at all times.
Has 5-Amino-1MQ been studied in people?
No published human studies turned up in our October 2026 review. The evidence note at the top of this page sums up what is known.
Sources
- Neelakantan et al., NNMT inhibitors reverse diet-induced obesity in mice PMCID PMC5826726
Doses tagged Community come from public dosing guides and user reports, checked against at least two of them. Those sites aren’t named here because many of them sell peptides or earn commissions on them.