This is the most speculative group on the site. Apart from SS-31’s approval for a rare disease, nothing here has trial evidence for energy or lifespan in healthy people.
SS-31 (elamipretide) is approved only for Barth syndrome, at 40 mg daily. The 1–10 mg ‘mito’ doses in circulation have no trial behind them.
NAD+ drips have to run slowly. A 750 mg infusion given over 6 hours in a research study caused no side effects; fast drips cause chest pressure and cramping.
Epithalon’s human data come from a related pineal extract studied by one group. Courses run 10–20 days, once or twice a year.
| Compound | Evidence | Common dose | Frequency | Cycle, first 26 weeks |
|---|---|---|---|---|
| NAD+Coenzyme | Human studies | 50–100 mg, 2–3× weekly | 2–3× per week | No set cycle |
| MOTS-cMitochondrial-derived peptide | Preclinical | 5 mg, 1–3× weekly | 1–3× per week | 8 weeks on, 4 off |
| SS-31Mitochondria-targeted peptide | Approved drug | Label 40 mg; community 1–10 mg daily | Once daily | 8 weeks on, 4 off |
| GlutathioneAntioxidant tripeptide | Approved drug | 200–600 mg, 2–3× weekly | 2–3× per week | No set cycle |
| EpithalonPineal bioregulator peptide | Preclinical | 5–10 mg daily for 10–20 days | Once daily during a course | 2-week course, about every 5 months |
| ThymalinImmune modulator (thymic extract) | Approved drug | 5–20 mg daily for 3–10 days | Once daily during a course | 1-week course, about every 4 months |
| PinealonShort bioregulator peptide | Preclinical | ~1 mg daily for 10–20 days | Once daily during a course | 2-week course, about every 6 months |
Each draw is worked out for the vial and water shown. The calculator can plan a whole run, including how many vials it takes.
| Period | Dose | Draw |
|---|---|---|
| Weeks 1–824 doses | 50 mg | 30 units |
Mixed as 500 mg + 3 mL (166.7 mg/mL). One vial holds 10 doses, about 3.3 weeks at this pace.
2–3 times a week under the skin. Larger doses usually go into muscle because SC shots sting.
| Period | Dose | Draw |
|---|---|---|
| Weeks 1–824 doses | 5 mg | 50 units |
Mixed as 10 mg + 1 mL (10 mg/mL). One vial holds 2 doses, about 5 days at this pace.
The most common schedule, on non-consecutive days. It copies the rhythm of mouse studies.
| Period | Dose | Draw |
|---|---|---|
| Days 1–1010 doses | 10 mg | 60 units |
Mixed as 50 mg + 3 mL (16.67 mg/mL). One vial holds 5 doses, about 5 days at this pace.
100 mg per course. Named for the Russian protocol, though the human data used the extract Epithalamin.
NAD+ commonly stings and can cause flushing or nausea. Slower injections and smaller doses help.
CommunityCDC linked 25+ illnesses in 2026 to endotoxin in supplement-grade glutathione given by IV, IM and SC injection. Ask whether the product is pharmaceutical grade.
Bioregulators like Epithalon, Pinealon and Thymalin are run in short blocks with months off, not continuously.
CommunityEnergy and wellbeing are easy to over-read. Track sleep, resting heart rate or training logs before and during.
Doses tagged Community come from public dosing guides and user reports, checked against at least two of them. Those sites aren’t named here because many of them sell peptides or earn commissions on them.
Each compound’s page lists its own sources.
The approved GLP-1 drugs, the newer investigational ones, and fat-loss peptides with far less evidence.
BPC-157, TB-500 and their blends, plus peptides aimed at joints, the gut and nerves.
GHRH analogs, ghrelin-receptor agonists, tesamorelin and IGF-1 LR3.
Copper peptides, a cosmetic peptide and the two melanotans.
Selank, Semax, their blend, Adamax, Pinealon, DSIP and Cerebrolysin.
PT-141, hCG, kisspeptin-10 and oxytocin.
Thymosin alpha-1, Thymalin, KPV and VIP.