Vial Guide

Gonadorelin 2 mg vial

How much bacteriostatic water to add to a 2 mg vial of Gonadorelin, the syringe units for each common dose, and how many doses the vial holds.

Water
2 mL
Strength
1 mg/mL
Common dose
100 mcg
Draw
10 units0.10 mL
Doses per vial
20

The short answer

Mixed with 2 mL of bacteriostatic water, a 2 mg vial of Gonadorelin holds 1 mg/mL. A 100 mcg dose is then 10 units (0.10 mL) on a U-100 insulin syringe, and the vial holds about 20 doses of that size. Taken 3× per week, it lasts about 6.7 weeks.

Approved drug. A copy of the body’s own GnRH, approved for decades. Both US products are gone: Factrel (1982) and Lutrepulse (1989) are listed as discontinued. Approved products remain in Europe, including the Lutrelef pump for hypothalamic amenorrhea and a 100 mcg diagnostic injection in the UK. Pump therapy has good evidence in fertility; the popular use alongside testosterone therapy has no controlled trial.
Gonadorelin page

How much water

The water only sets the strength; the dose and the number of doses in the vial stay the same. Draws are on a U-100 insulin syringe, where 1 unit is 0.01 mL.

Water addedStrengthPer syringe unitDraw for 100 mcg
1 mL2 mg/mL20 mcg5 units (0.05 mL)
2 mL1 mg/mL10 mcg10 units (0.10 mL)
3 mL0.6667 mg/mL6.7 mcg15 units (0.15 mL)

Dose chart

Syringe units for each common dose at each water volume. Select a cell to open it in the calculator.

DoseWater added
1 mL2 mL3 mL
50 mcg
60 mcg
75 mcg
100 mcg
150 mcg
200 mcg

Draws over 100 units show in mL. Faded values are under 2 units, which is hard to measure. Check that your vial holds the larger volumes.

Where the doses come from

  • Label Diagnostic test: a single 100 mcg dose under the skin or into a vein, with LH measured before the dose and at 15, 30, 45, 60 and 120 minutes.
  • Trial Pulsatile pump: 10 mcg under the skin every 90 minutes, adjusted to keep LH and FSH in range; ovulation-induction practice uses about 5–20 mcg per pulse every 60–120 minutes.
  • Community 100–200 mcg under the skin, 2–3× weekly alongside testosterone therapy; some guides argue the short half-life makes daily dosing the minimum.

Doses are what labels, trials or community reports reference, not recommendations. Gonadorelin’s page has the cycle, side effects, cautions and sources.

Mixing and storage

  1. PrepareLet a refrigerated vial come to room temperature, and wipe both stoppers with an alcohol swab.
  2. Add 2 mLDraw 2 mL of bacteriostatic water and let it run slowly down the inside wall of the vial.
  3. Swirl, don’t shakeSwirl gently until the powder dissolves and the liquid is clear.
  4. Label itWrite the date and the strength, 1 mg/mL, on the vial.

Storage: Research vials, mixed: 2–8 °C, use within about 4 weeks. The approved vial is stored below 25 °C and used within 24 hours of mixing.

The reconstitution guide covers each step, and the units page explains syringe markings.

Questions

How much water do I add to a 2 mg vial of gonadorelin?

There’s no single right amount: the water only sets the strength. With 2 mL of bacteriostatic water, a 2 mg vial holds 1 mg/mL. With 1 mL it’s 2 mg/mL; with 3 mL it’s 0.6667 mg/mL. Less liquid makes each dose a smaller draw; more makes small doses easier to measure.

How many units is 100 mcg of gonadorelin?

With 2 mL in a 2 mg vial, 100 mcg is 10 units (0.10 mL) on a U-100 insulin syringe. With 1 mL, 5 units (0.05 mL); with 3 mL, 15 units (0.15 mL).

How many doses are in a 2 mg vial of gonadorelin?

About 20 doses of 100 mcg, or 13 of 150 mcg or 10 of 200 mcg. Taken 3× per week at 100 mcg, it lasts about 6.7 weeks.

How long does a mixed vial of gonadorelin keep?

Research vials, mixed: 2–8 °C, use within about 4 weeks. The approved vial is stored below 25 °C and used within 24 hours of mixing.

Other vial sizes

Sources

  • Gonadorelin 100 micrograms powder for solution for injection (HRF), UK summary of product characteristics, revised 30 August 2022
  • FDA Drugs@FDA records for Factrel (NDA 018123, approved 1982) and Lutrepulse (NDA 019687, approved 1989), both discontinued
  • Mao et al., pulsatile GnRH versus combined gonadotropin therapy in congenital hypogonadotropic hypogonadism (Asian J Androl 2017) PMID 28051040
  • Quaas et al., pulsatile GnRH in functional hypothalamic amenorrhea, 25-year cohort (J Assist Reprod Genet 2022) PMID 36378460
  • FDA, bulk drug substances nominated for use in compounding under section 503B, categories 1 to 3 (updated March 21, 2025)

The math on this page uses the doses and storage on Gonadorelin’s page.

By Vial Guide editorsLast reviewed

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